PXD057036 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Gamma secretase complex and DOCK2 affinity interactome. |
| Description | γ-secretase is a transmembrane protease complex responsible for processing multiple type I transmembrane proteins, including the amyloid precursor protein and NOTCH. Despite various γ-secretase inhibitors and modulators developed in the past decades to target Notch-dependent cancers, their clinical use is still limited due to the low substrate specificity and on-target gut toxicity. Using a proteomics-based screening approach, we found that the dedicator of cytokinesis protein 2 (DOCK2) interacts with the γ-secretase complex component Nicastrin, regulating Nicastrin N45-mannosidation and γ-secretase activity towards NOTCH receptors. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-31 |
| AnnouncementXML | Submission_2026-07-30_19:37:06.996.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD057036 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | bian weixiang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-21 19:34:22 | ID requested | |
| ⏵ 1 | 2026-07-30 19:37:07 | announced | |
Publication List
Keyword List
| submitter keyword: Nicastrin, DOCK2, leukemia, Gamma secretase,NOTCH |
Contact List
| Xu Li |
|---|
| contact affiliation | School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China |
| contact email | lixu@westlake.edu.cn |
| lab head | |
| bian weixiang |
|---|
| contact affiliation | Westlake University |
| contact email | bianweixiang@westlake.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD057036 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD057036
- Label: PRIDE project
- Name: Gamma secretase complex and DOCK2 affinity interactome.
