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PXD057007

PXD057007 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of wild type and Nsun7 knockout mice testis
DescriptionInvestigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal columns of the fibrous sheath. The whole testis proteomes of wild type and Nsun7 knockout mice were obtained to study the molecular pathways affected by NSUN7.
HostingRepositoryPRIDE
AnnounceDate2025-03-07
AnnouncementXMLSubmission_2025-03-07_07:05:16.388.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEkaterina Guseva
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-21 03:42:18ID requested
12025-03-07 07:05:16announced
Publication List
10.1261/RNA.080320.124;
Keyword List
submitter keyword: Testis, Nsun7, spermatogenesis, longitudinal columns, methyltransferase
Contact List
Petr Sergiev
contact affiliationLomonosov Moscow State University
contact emailpetya@genebee.msu.ru
lab head
Ekaterina Guseva
contact affiliationLomonosov Moscow State University
contact emaileguseva98@mail.ru
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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