PXD056999

PXD056999 is an original dataset announced via ProteomeXchange.

Title	Proteomics characterizing the mechanisms of semaglutide in diabetes mice with cognitive impairment
Description	This study aims to investigate the neuroprotective effects of semaglutide in Diabetes-associated cognitive decline (DACD), while also exploring the underlying mechanisms targeting anti-oxidative effects.Methods: This study evaluated the antioxidant properties of semaglutide in a DACD model. To investigate the underlying mechanisms, we employed omics technologies. Proteomic analyses of the cells were conducted to identify the pathways responsible for the observed antioxidant effects.
HostingRepository	iProX
AnnounceDate	2024-10-21
AnnouncementXML	Submission_2025-08-21_20:28:43.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-21 00:11:14	ID requested
1	2024-12-30 21:21:16	announced
⏵ 2	2025-08-21 20:28:43	announced	2025-08-22: Add info.

Yang Y, Song L, Yu L, Zhang J, Zhang B, Transcriptomics and proteomics characterizing the antioxidant mechanisms of semaglutide in diabetic mice with cognitive impairment. Int J Mol Med, 55(4):(2025) [pubmed]

submitter keyword: Proteomics, Diabetes, Semaglutide

Bo Zhang
contact affiliation	China-Japan Friendship Hospital
contact email	drbozhang@yeah.net
lab head
Ying Yang
contact affiliation	China-Japan Friendship Hospital
contact email	yangying1115@126.com
dataset submitter

iProX dataset URI