PXD056997
PXD056997 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of acetylation sites of TRPV4 protein in mouse liver |
| Description | Prenatal development may adopt unique patterns of metabolic responses to different nutrient supplies. AMPK and mTOR are two central metabolic regulators, with AMPK acting to slow down and mTOR to promote anabolism. Here, we observed surprisingly that mTORC1 in the foetal liver remains active in low glucose, although AMPK is effectively activated in an AMP-dependent manner. Mechanistically, we found that TRPV4, one main member of TRPVs in the liver, is acetylated, disabling its inactivation by FBP-unoccupied aldolase. It suggested that the TRPV-mediated resistance of mTORC1 inhibition in low glucose for normal foetal development. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-21 |
| AnnouncementXML | Submission_2024-10-21_00:07:37.088.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuanjin Yu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-21 00:07:17 | ID requested | |
| ⏵ 1 | 2024-10-21 00:07:37 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: mTOR, Mouse liver, TRPV4 protein acetylation |
Contact List
| Hefeng Huang | |
|---|---|
| contact affiliation | Zhejiang University School of Medicine |
| contact email | huanghefg@hotmail.com |
| lab head | |
| Chuanjin Yu | |
| contact affiliation | Institute of Reproduction and Development, Fudan University |
| contact email | yuchuanjin1013@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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