PXD056926
PXD056926 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Fusing Engineered Bacterial Strains with NIR-II AIEgen for Multimodal Image-guided Phototherapy and Immunotherapy |
| Description | we present an aggregation-induced emission (AIE) - bacteria hybrid bionic robot to address the above issues. This bionic robot is composed of a multifunctional AIE molecule, INX-2 and Escherichia coli Nissle 1917 (EcN), i.e. EcN@INX-2. The robot is characterized by NIR-II fluorescence emission with efficient photodynamic and photothermal effects and tumor targeting, which was realized by INX-2 and EcN respectively, EcN@INX-2 achieved in vivo multimodal imaging and therapy of the tumors through multiple mechanisms including the activation of anti-tumor immunity, photodynamic and photothermal therapy in CT26 tumor-bearing female mice. |
| HostingRepository | iProX |
| AnnounceDate | 2024-10-18 |
| AnnouncementXML | Submission_2025-08-21_20:12:57.637.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Liwei Zhu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-17 20:23:29 | ID requested | |
| 1 | 2024-10-17 20:23:42 | announced | |
| ⏵ 2 | 2025-08-21 20:12:58 | announced | 2025-08-22: Add info. |
Publication List
| Zhu L, Song G, Zhang W, Wu Y, Chen Y, Song J, Wang D, Li G, Tang BZ, Li Y, Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy. Nat Commun, 16(1):2578(2025) [pubmed] |
Keyword List
| submitter keyword: Aggregation-induced emission, Bacteria, Bionic Robot, Phototheranostics, Immunotherapy |
Contact List
| Ying Li | |
|---|---|
| contact affiliation | Guangzhou Medical University Innovation Research Center for AIE Pharmaceutical Biology |
| contact email | liying@gzhmu.edu.cn |
| lab head | |
| Liwei Zhu | |
| contact affiliation | Guangzhou Medical University Innovation Research Center for AIE Pharmaceutical Biology |
| contact email | 337864188@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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