PXD056906

PXD056906 is an original dataset announced via ProteomeXchange.

Title	Theileria annulata infectied bos taurus extracellular vesicles LC-MSMS
Description	Extracellular vesicles (EVs) are key mediators of intercellular communication, and often play critical roles in host-parasite interactions by facilitating parasite’s physiology and pathogenesis. Theileria annulata, an apicomplexan parasite, induces profound changes in host cells, leading to uncontrolled proliferation, apoptosis resistance, and increased invasiveness. In this study, we performed the comprehensive proteomic and small RNA analysis of EVs isolated from a T. annulata Kashi isolate-infected bovine lymphocyte cell line (TaXJS), B cell line (TaBC), dendritic cell line (TaDC), and from the sera of cattle before and after infection. Our label-free LC-MS/MS proteomics identified 2580 proteins, while small RNA sequencing revealed 6635 miRNAs associated with parasite development, host invasion, and immune evasion. Functional enrichment analyses recognized vesicular components involved in key pathways of the parasite-host such as ECM-receptor interaction, oxidative phosphorylation, and proton transport. These findings highlight the potential of Theileria-derived EVs in modulating host responses and their potential as therapeutic and vaccine targets.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-29_01:16:21.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yijun Chai
SpeciesList	scientific name: Theileria annulata; NCBI TaxID: 5874; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-17 05:53:53	ID requested
⏵ 1	2025-09-29 01:16:21	announced

10.1186/S13071-025-06834-8;

submitter keyword: dendritic cells,bos taurus,B cells,serum,Theileria annulata,PBMC,LC-MSMS

Yijun Chai
contact affiliation	Lanzhou Veterinary Research Institute,Chinese Academy Agricultrural Sciences,China
contact email	chaiyijun01@163.com
lab head
Yijun Chai
contact affiliation	Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
contact email	chaiyijun01@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD056906

PRIDE project URI

• PRIDE
  1. PXD056906
     1. Label: PRIDE project
     2. Name: Theileria annulata infectied bos taurus extracellular vesicles LC-MSMS