⮝ Full datasets listing
PXD056881
PXD056881 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome Profiling of human astrocytes upon both positive and negative actuations of G-quadruplex control systems |
| Description | We report here on an unprecedented comparison of the cellular consequences of G4 chemical stabilization by pyridostatin (PDS) and destabilization by phenylpyrrolocytosine (PhpC) at both transcriptome- and proteome-wide scales in patient-derived human brain cells. Our results show that the stabilization of G4s by PDS triggers the dysregulation of many cellular circuitries, the most drastic effects originating in the downregulation of 158 proteins primarily involved in RNA transactions. In contrast, the destabilization of G4s by PhpC modulates the G4 landscapes in a far more focused manner with the upregulation of 295 proteins mostly involved in RNA transactions as well, thus mirroring the effects of PDS. Our study is the first of its kind to report on the extent of G4-associated cellular circuitries in human cells by systematically pitting the effect of G4 stabilization against destabilization in a direct and unbiased manner. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-17 |
| AnnouncementXML | Submission_2026-08-17_15:28:20.920.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sung Yun Jung |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-16 21:41:16 | ID requested | |
| ⏵ 1 | 2026-08-17 15:28:21 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Human Astrocytes, G-quadruplex, DatasetType:Proteomics |
Contact List
| Andrey S. Tsvetkov | |
|---|---|
| contact affiliation | The University of Texas Health Science Center at Houston |
| contact email | Andrey.S.Tsvetkov@uth.tmc.edu |
| lab head | |
| Sung Yun Jung | |
| contact affiliation | Baylor College of Medicine |
| contact email | syjung@bcm.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000096114/ |
