PXD056842

PXD056842 is an original dataset announced via ProteomeXchange.

Title	IDH2 lactylation promotes angiogenesis in diabetic myocardial infarction
Description	Compensatory angiogenesis is crucial for recovery in patients with diabetic myocardial infarction (DMI), yet effective interventions are still unclear. This study employed liquid chromatography-tandem mass spectrometry to identify lactylated proteins in the infarct border zone of DMI mouse hearts. Our findings revealed that IDH2 is lactylated at lysine 272, enhancing its binding to Cav1 while inhibiting the Cav1-eNOS interaction. This modification promotes eNOS activity and facilitates the proliferation, migration, and angiogenesis of cardiac microvascular endothelial cells under high glucose and hypoxic conditions. In endothelial cell-specific IDH2-K272R knock-in mice, the loss of K272 lactylation impairs cardiac function and exacerbates pathological remodeling due to disrupted angiogenesis.
HostingRepository	iProX
AnnounceDate	2024-10-16
AnnouncementXML	Submission_2025-10-09_01:18:00.698.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhongqun Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	lactic acid
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-16 00:45:01	ID requested
⏵ 1	2025-10-09 01:18:01	announced

Dataset with its publication pending

submitter keyword: Diabetes, Myocardial infarction, Angiogenesis, IDH2, Lactylation

Zhongqun Wang
contact affiliation	Affiliated Hospital of Jiangsu University
contact email	wangtsmc@126.com
lab head
Zhongqun Wang
contact affiliation	Affiliated Hospital of Jiangsu University
contact email	wangtsmc@126.com
dataset submitter

iProX dataset URI