PXD056826 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Transgenic sickle cell mouse plasma and brain |
| Description | Sickle cell disease (SCD) is a genetic disorder caused by a mutation in the beta hemoglobin gene, resulting in red blood cell distortion, hemolysis, and severe pain episodes. Chronic pain in SCD is believed to be largely driven by neuroinflammation and central sensitization, yet the exact neurobiological mechanisms remain unclear. Hemorphins, opioid peptides derived from beta-hemoglobin, may bridge this gap by influencing opioid signaling pathways that could alleviate the pain experienced in SCD. In this study, we investigated the levels of hemorphins in both plasma and brain tissues of transgenic SCD mice using liquid chromatography-mass spectrometry (LC-MS). |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-25 |
| AnnouncementXML | Submission_2025-11-25_15:33:41.505.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanqi Tan |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Bruker Daltonics timsTOF series |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-15 14:37:40 | ID requested | |
| ⏵ 1 | 2025-11-25 15:33:42 | announced | |
Publication List
Keyword List
| submitter keyword: peptidomics, proteomics, LC-MS,sickle cell |
Contact List
| Jonathan V. Sweedler |
|---|
| contact affiliation | University of Illinois Urbana-Champaign, Department of Chemistry |
| contact email | jsweedle@illinois.edu |
| lab head | |
| Yanqi Tan |
|---|
| contact affiliation | University of Illinois Urbana Champaign |
| contact email | tan61@illinois.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD056826 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056826
- Label: PRIDE project
- Name: Transgenic sickle cell mouse plasma and brain
