PXD056820
PXD056820 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ro5-4864, a Ligand of the Mitochondrial Translocator Protein, Protects Against Heart Failure in Mice |
| Description | The 18-kDa mitochondrial translocator protein (TSPO), likely through its interaction with the voltage-dependent anion channel (VDAC), has been shown to modulate mitochondrial function and the cardiac response to pressure overload. We have previously shown that conditional knockout of TSPO limited the development of heart failure in the murine model of transverse aortic constriction (TAC). In this study, we tested the hypothesis that similar protection could be achieved by a ligand of TSPO, Ro5-4864 (Ro5), in in-vivo animal model of pressure-overload induced heart failure. To elucidate mechanisms, we performed proteomic and western blot analysis of cardiac tissue after 8 weeks of TAC in mice treated and untreated with Ro5. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-10-15 |
| AnnouncementXML | Submission_2024-10-15_10:03:48.273.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | gabriela grigorean |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Oxidation; Acetyl |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-10-15 09:24:51 | ID requested | |
| ⏵ 1 | 2024-10-15 10:03:48 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart failure, mitochondria, oxidative stress, translocator protein, inflammation, DatasetType:Proteomics |
Contact List
| Saul Schaefer | |
|---|---|
| contact affiliation | University of California, Davis |
| contact email | sschaefer@ucdavis.edu |
| lab head | |
| gabriela grigorean | |
| contact affiliation | ucd |
| contact email | ggrigorean@ucdavis.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000096098/ |
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