PXD056789

PXD056789 is an original dataset announced via ProteomeXchange.

Title	Human adventitial and medial layers from AAA aorta LC-MS/MS
Description	Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of a number of pathological mechanisms contributing to the dilation of the human AAA wall, there is currently no specific therapy to prevent the fatal rupture of the aorta. Our objective was to identify novel mediators and/or biomarkers involved in the instability of the aortic wall that could help to prevent AAA progression.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:37:32.587.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Estefanía Núñez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-14 09:30:08	ID requested
⏵ 1	2025-07-13 16:37:33	announced

10.1186/s12967-025-06758-y;

Cerro-Pardo I, N, ú, ñ, ez E, Picatoste B, M, á, rquez-G, á, lvez C, Ortega-Villanueva L, Raposo-Guti, é, rrez I, Lindholt JS, Blanco-Colio LM, Ramiro AR, V, á, zquez J, Mart, í, n-Ventura JL, Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics. J Transl Med, 23(1):747(2025) [pubmed]

submitter keyword: Human, aorta, AAA, LC-MS/MS

Jesús Vázquez
contact affiliation	Laboratorio de Proteómica Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (Spain)
contact email	enunez@cnic.es
lab head
Estefanía Núñez
contact affiliation	Centro Nacional de Investigaciones Cardiovasculares
contact email	enunez@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD056789

PRIDE project URI

• PRIDE
  1. PXD056789
     1. Label: PRIDE project
     2. Name: Human adventitial and medial layers from AAA aorta LC-MS/MS