PXD056748

PXD056748 is an original dataset announced via ProteomeXchange.

Title	Integrated Proteogenomic Characterization of Localized Prostate Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies
Description	We profiled the genome, transcriptome, proteome and phosphoproteome of 145 cases of localized prostate cancer (PCa) in Chinese patients and revealed three subtypes with distinct molecular features. We integrated multi-omic data to refine molecular subtyping of localized PCa, and identified NANS as a potential prognostic biomarker and therapeutic option for aggressive PCa.
HostingRepository	iProX
AnnounceDate	2024-10-23
AnnouncementXML	Submission_2025-04-15_01:22:04.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinxin Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-11 20:46:55	ID requested
⏵ 1	2025-04-15 01:22:05	announced

Ou W, Zhang XX, Li B, Tuo Y, Lin RX, Liu PF, Guo JP, Un HC, Li MH, Lei JH, Gao XJ, Zheng FF, Chen LW, Long LL, Wang ZR, Integrated proteogenomic characterization of localized prostate cancer identifies biological insights and subtype-specific therapeutic strategies. Nat Commun, 16(1):3189(2025) [pubmed]

submitter keyword: prostate cancer, proteomics

Zongren Wang
contact affiliation	The First Affiliated Hospital, Sun Yat-sen University
contact email	wangzr27@mail.sysu.edu.cn
lab head
Xinxin Zhang
contact affiliation	The First Affiliated Hospital, Sun Yat-sen University
contact email	diluczhang@foxmail.com
dataset submitter

iProX dataset URI