PXD056745

PXD056745 is an original dataset announced via ProteomeXchange.

Title	Proteomic and phosphoproteomic characteristics of multiple brain regions in SARS-CoV-2 Omicron strain-infected rhesus
Description	Compared to the original Alpha variant, the novel coronavirus Omicron variant, as the main pathogen causing the global COVID-19 pandemic, exhibits stronger transmissibility. Although its pathogenicity has weakened, studies have shown that infection with the Omicron variant can still lead to neurological sequelae such as brain fog, taste and smell disorders, and headaches. To further investigate the molecular mechanisms of COVID-19 neurological sequelae such as brain fog and to advance drug target discovery, in this project, we conducted liquid chromatography-mass spectrometry (LC-MS) based proteomic and phosphoproteomic analyses on the frontal lobe, occipital lobe, parietal lobe, temporal lobe, cerebellum, and brainstem of rhesus monkeys infected with the SARS-CoV-2 Omicron variant. We found that the six brain regions showed specificity in their response to SARS-CoV-2 infection, but all exhibited immune responses. The differentially expressed proteins and predicted kinases identified in this study can serve as targets for screening candidate therapeutic drugs for COVID-19.
HostingRepository	iProX
AnnounceDate	2024-10-11
AnnouncementXML	Submission_2025-07-30_19:49:59.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiaochu Wang
SpeciesList	scientific name: Macaca mulatta; NCBI TaxID: 9544;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-11 20:39:38	ID requested
⏵ 1	2025-07-30 19:49:59	announced

Dataset with its publication pending

submitter keyword: Brain, Proteomic, SARS-CoV-2 Omicron strain, Neurological dysfunction, Rhesus macaques

Juntao Yang
contact affiliation	State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
contact email	yangjt@pumc.edu.cn
lab head
Qiaochu Wang
contact affiliation	State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
contact email	wangqiaochu@student.pumc.edu.cn
dataset submitter

iProX dataset URI