PXD056666 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deep phosphoproteomic analaysis of the response to EGF in HEK293 cells |
| Description | In this study, we adopt the perspective of a naive researcher with the goal of learning a new signaling pathway, starting from differential phosphoproteomic data and a kinase-substrate network. Focusing on the well-characterized epidermal growth factor (EGF) response, we perform a meta-analysis of recent studies and complement those with three deep and time-resolved phosphoproteomic experiments. We also combine multiple kinase-substrate networks using protein language models and data from peptide-array screenings, generating a state-of-the-art resource. We use these datasets and networks to generate context-specific signaling subnetworks through various computational approaches, and compare the results to different sets of ground truth interactions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-05 |
| AnnouncementXML | Submission_2026-02-05_10:11:08.430.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Martin Garrido-Rodriguez |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-09 13:59:39 | ID requested | |
| ⏵ 1 | 2026-02-05 10:11:08 | announced | |
Publication List
Keyword List
| submitter keyword: Phosphoproteomics |
Contact List
| Mikhail Savitski |
|---|
| contact affiliation | Molecular Systems Biology unit, EMBL, Heidelberg, Germany |
| contact email | mikhail.savitski@embl.de |
| lab head | |
| Martin Garrido-Rodriguez |
|---|
| contact affiliation | EMBL |
| contact email | martin.garrido@embl.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD056666 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056666
- Label: PRIDE project
- Name: Deep phosphoproteomic analaysis of the response to EGF in HEK293 cells
