PXD056639

PXD056639 is an original dataset announced via ProteomeXchange.

Title	Chemoproteomic profiling reveals the mechanism of bile acid tolerance in pathogens
Description	As amphipathic molecules, BAs have strong antibacterial effects, preventing overgrowth of the gut microbiota and defending the invasion of pathogens. However, some disease-causing pathogens can survive from the BA stress and knowledge is limited about how they develop BA tolerance. In the current study, we applied a quantitative chemoproteomic strategy to profile BA-interacting proteins in bacteria, aiming to discover the sensing pathway of BAs. By using the clickable and photo-affinity analogue BA probes with quantitative mass spectrometry, we identified 588 CA-interacting proteins and 435 DCA-interacting proteins.
HostingRepository	iProX
AnnounceDate	2024-10-09
AnnouncementXML	Submission_2024-12-25_18:49:45.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Biwei Liu
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-09 00:30:28	ID requested
1	2024-10-09 00:30:43	announced
⏵ 2	2024-12-25 18:49:46	announced	2024-12-26: Add Publication.

Liu B, Zhuang S, Tian R, Liu Y, Wang Y, Lei X, Wang C, Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria. ACS Chem Biol, 17(9):2461-2470(2022) [pubmed]

submitter keyword: Bile acids, Chemoproteomics

Chu Wang
contact affiliation	Peking University
contact email	chuwang@pku.edu.cn
lab head
Biwei Liu
contact affiliation	Peking University
contact email	liubiwei1994@pku.edu.cn
dataset submitter

iProX dataset URI