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PXD056595

PXD056595 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
DescriptionMLKL, as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate post-hemorrhagic stroke damage. However, there is no direct evidence supporting MLKL as a drug target for hemorrhagic stroke currently, and the precise mechanisms by which MLKL functions in this context remain unclear. Here, we established an intracerebral hemorrhage model by collagenase IV injection and found that MLKL knockout alone was insufficient to fully reverse neuroinflammation and pathological damage. To further elucidate the molecular mechanisms underlying the effects of MLKL knockout on the ICH model, we conducted a proteomic analysis via LC-MS/MS. While MLKL knockout did not significantly reverse the damage caused by intracerebral hemorrhage, enhanced pathways related to inflammation, metabolism, and coagulation as well as attenuated functions related to neuron assemble were identified, suggesting that MLKL may exert its effects through these pathways. Based on these findings, we hypothesize that co-targeting MLKL and its associated protein network may yield better therapeutic outcomes for hemorrhagic stroke.
HostingRepositoryiProX
AnnounceDate2024-09-27
AnnouncementXMLSubmission_2024-10-08_01:08:45.130.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJingbo Qie
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-08 01:08:33ID requested
12024-10-08 01:08:45announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: MLKL, hemorrhagic stroke
Contact List
Jingbo Qie
contact affiliationFudan University
contact emailjingboqie@fudan.edu.cn
lab head
Jingbo Qie
contact affiliationFudan University
contact emailqiejingbo@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI