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PXD056588

PXD056588 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of TRADD phosphorylation sites
DescriptionWe re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next performed in vitro kinase assay using recombinant human TAK1 and human TRADD, followed by mass spectrometry to identify the sites directly phosphorylated by TAK1.
HostingRepositoryiProX
AnnounceDate2024-10-05
AnnouncementXMLSubmission_2024-10-08_00:56:57.687.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBing Shan
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-08 00:56:47ID requested
⏵ 12024-10-08 00:56:58announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: TRADD binding phosphorylation sites
Contact List
Junying Yuan
contact affiliationShanghai Institute of Organic Chemistry, CAS
contact emailjunying_yuan@sioc.ac.cn
lab head
Bing Shan
contact affiliationShanghai Institute of Organic Chemistry, CAS
contact emailshanbing@sioc.ac.cn
dataset submitter
Full Dataset Link List
iProX dataset URI

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