PXD056585

PXD056585 is an original dataset announced via ProteomeXchange.

Title	The influence of IL-1β and TNF-α on the tenogenic differentiation of human periodontal ligament stem cells via global proteomic analysis
Description	The hPDLSCs were cultured in the tenogenic medium treated with 0.1 ng/ml IL-1β or 10 ng/ml TNF-α for 7 days. Total proteins were isolated from the collected cell samples. Subsequently, the LFQ-based proteomic analysis was conducted for the extracted proteins in each group as established procedures [59]. Differential expression analysis was performed by comparing the expression levels of the identified proteins in the hPDLSCs treated with IL-1β or TNF-α with those in the Ctrl group.
HostingRepository	iProX
AnnounceDate	2024-10-05
AnnouncementXML	Submission_2025-09-03_00:15:34.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Renwang Sheng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap; LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-08 00:25:38	ID requested
1	2024-10-08 00:30:58	announced
⏵ 2	2025-09-03 00:15:36	announced	2025-09-03: Add info.

Chen J, Sheng R, Mo Q, Backman LJ, Lu Z, Long Q, Chen Z, Cao Z, Zhang Y, Liu C, Zheng H, Qi Y, Cao M, Rui Y, Zhang W, B signaling. Bioact Mater, 44():319-338(2025) [pubmed]

submitter keyword: IIL-1β, TNF-α, hPDLScs, inflammation, tenogenesis

Jialin Chen
contact affiliation	Southeast University
contact email	jialin.chen@seu.edu.cn
lab head
Renwang Sheng
contact affiliation	Southeast University
contact email	srenwang@seu.edu.cn
dataset submitter

iProX dataset URI