PXD056556

PXD056556 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ROR2 drives right ventricular heart failure via disruption of proteostasis
Description	This study assessed the impact of ROR2 expression on the global proteome using neonatal rat ventricular myocytes (NRVMs) using adenovirus to overexpress ROR2 vs control NRVMs with and without MG132 to block the proteasome to characterize proteasome-mediated clearance.
HostingRepository	PRIDE
AnnounceDate	2026-04-28
AnnouncementXML	Submission_2026-04-27_18:09:52.829.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jonathan Edwards
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-07 10:14:21	ID requested
⏵ 1	2026-04-27 18:09:53	announced

Publication List

Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ, ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv, ():(2025) [pubmed]
10.1101/2025.02.01.635961;

Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ, ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv, ():(2025) [pubmed]

10.1101/2025.02.01.635961;

Keyword List

submitter keyword: Proteostasis, ROR2,cardiomyocyte

submitter keyword: Proteostasis, ROR2,cardiomyocyte

Contact List

Jonathan Joseph Edwards
contact affiliation	Children's Hospital of Philadelphia
contact email	edwardsj6@chop.edu
lab head
Jonathan Edwards
contact affiliation	Children's Hospital of Philadelphia
contact email	edwardsj6@chop.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD056556
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD056556

PRIDE project URI

Repository Record List

[ + ]