PXD056544

PXD056544 is an original dataset announced via ProteomeXchange.

Title	Nerve activity inhibits mTORC1-dependent protein synthesis in skeletal muscle
Description	To find out intracellular signaling pathways regulting fiber type specific muscle wasting we generated a new mouse model, which allows us to label specifically muscle proteins. Interestingly, we observed that loss of muscle activity by denervation induces a strong increase of protein labeling in oxidative, mitochondria-rich muscle fibers. MS-based analysis, rapamycin treatments and genetic models showed requirement of mTORC1 signaling for increased protein synthesis in dependence of nerve activity.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:55:49.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frederik Tellkamp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-07 05:17:12	ID requested
⏵ 1	2025-05-07 03:55:50	announced

10.1126/sciadv.adt4955;

Dumitras AG, Piccoli G, Tellkamp F, Keufgens L, Baraldo M, Zorzato S, Cussonneau L, Nogara L, Kr, ü, ger M, Blaauw B, Neural stimulation suppresses mTORC1-mediated protein synthesis in skeletal muscle. Sci Adv, 11(14):eadt4955(2025) [pubmed]

submitter keyword: skeletal muscle,mTORC1, protein synthesis

Bert Blaauw
contact affiliation	Venetian Institute of Molecular Medicine (VIMM), Via Orus 2, 35129, Padova, Italy
contact email	bert.blaauw@unipd.it
lab head
Frederik Tellkamp
contact affiliation	University of Cologne, Department of Biology, Institute for Genetics
contact email	frederik.tellkamp@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD056544

PRIDE project URI

• PRIDE
  1. PXD056544
     1. Label: PRIDE project
     2. Name: Nerve activity inhibits mTORC1-dependent protein synthesis in skeletal muscle