PXD056504 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides |
Description | A unified synthesis of skeletally-diverse sulfonyl fluorides was developed that relied upon photoredox-catalysed dehydrogenative couplings between hetaryl sulfonyl fluorides and hydrogen donor building blocks. A set of 32 diverse probes were prepared, and then screened against Trypanosoma brucei. Four of the probes were found to have sub-micromolar anti-trypanosomal activity. A chemical proteomic approach, harnessing an alkynylated analogue and broad-spectrum fluorophosphonate tools, provided insights into the observed anti-trypanosomal activity, which likely stems from covalent modification of multiple protein targets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:12:03.334.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Brian Suarez-Mantilla |
SpeciesList | scientific name: Trypanosoma brucei; NCBI TaxID: 5691; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-10-04 07:36:44 | ID requested | |
⏵ 1 | 2024-10-17 02:12:03 | announced | |
Publication List
Keyword List
submitter keyword: Medicinal chemistry, photoredox chemistry, Chemoproteomics, Sulfonyl fluoride |
Contact List
Adam Nelson |
contact affiliation | Professor of Chemical Biology School of Chemistry University of Leeds LS2 9JT |
contact email | a.s.nelson@leeds.ac.uk |
lab head | |
Brian Suarez-Mantilla |
contact affiliation | School of Chemistry, University of Leeds |
contact email | B.A.SuarezMantilla@leeds.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD056504 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056504
- Label: PRIDE project
- Name: Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides