PXD056499

PXD056499 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative proteomics reveals inflammatory signaling in golgin-97 knockout-mediated breast cancer progression
Description	The Golgi apparatus serves as a central hub for trafficking, regulating the anterograde transport and modification of proteins and lipids, or recycling extracellular proteins via retrograde transport through endosomes. Several Golgi-localized proteins have been reported to be involved in regulating cancer cell migration and invasion. Our previous study showed that the Golgi tethering factor golgin-97 is downregulated in breast cancer and is correlated with patient prognosis. Here, we demonstrated that the knockout of golgin-97 promotes tumor malignancy in breast cancer in vivo. We identified differentially expressed proteins between golgin-97 knockout cells and their parental breast cells using a quantitative proteomic approach based on 6-plex tandem mass tags (TMT) technology. Bioinformatics analysis further revealed that golgin-97 knockout was significantly related to inflammation-related factors and MAPK signaling pathways. We also integrated proteomic and genomic datasets to explore the biological impacts of golgin-97 in regulating breast cancer progression.
HostingRepository	PRIDE
AnnounceDate	2025-03-07
AnnouncementXML	Submission_2025-03-06_20:51:49.666.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chia-Jung Yu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-04 06:08:01	ID requested
⏵ 1	2025-03-06 20:51:50	announced

Publication List

10.1186/s12964-024-02010-0;
Liu YC, Lin TJ, Chong KY, Chen GY, Kuo CY, Lin YY, Chang CW, Hsiao TF, Wang CL, Shih YC, Yu CJ, Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer. Cell Commun Signal, 23(1):22(2025) [pubmed]

10.1186/s12964-024-02010-0;

Liu YC, Lin TJ, Chong KY, Chen GY, Kuo CY, Lin YY, Chang CW, Hsiao TF, Wang CL, Shih YC, Yu CJ, Targeting the ERK1/2 and p38 MAPK pathways attenuates Golgi tethering factor golgin-97 depletion-induced cancer progression in breast cancer. Cell Commun Signal, 23(1):22(2025) [pubmed]

Keyword List

submitter keyword: breast cancer, golgin-97, inflammatory,Golgi, metastasis

submitter keyword: breast cancer, golgin-97, inflammatory,Golgi, metastasis

Contact List

Chia-Jung Yu
contact affiliation	Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact email	yucj1124@gmail.com
lab head
Chia-Jung Yu
contact affiliation	Department of Cell and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
contact email	yucj1124@mail.cgu.edu.tw
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD056499
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD056499

PRIDE project URI

Repository Record List

[ + ]