PXD056467

PXD056467 is an original dataset announced via ProteomeXchange.

Title	Diversification of DIX domain-containing proteins in the SAR supergroup
Description	Polarity establishment is crucial for development, cellular organization, and signaling in living organisms. In animals and plants, this process involves DIX domain-containing proteins (DDPs) that assemble into oligomers via head-to-tail DIX polymerization, facilitating localized protein aggregation. This study uncovers the unexpected diversity of DDPs within the SAR supergroup, characterizing four DDPs with novel domain combinations conserved in Stramenopiles and Alveolates. These proteins are predominantly found in micro-swimmers and species with a motile stage in their life cycle. We hypothesize that DDPs from these eukaryotic lineages may be involved in cell polarity-related processes, including those associated with motility. Our work provides insights for further investigations of DDPs in protists and will enable the development of evolution-informed control strategies against pathogens and parasites within this clade.
HostingRepository	PRIDE
AnnounceDate	2025-03-27
AnnouncementXML	Submission_2025-03-27_13:25:35.285.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD056467
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Edouard Evangelisti
SpeciesList	scientific name: Phytophthora palmivora; NCBI TaxID: 4796;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive; Dionex instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-02 22:11:39	ID requested
⏵ 1	2025-03-27 13:25:35	announced

10.6019/PXD056467;

submitter keyword: Stramenopiles, oomycetes,DIX domain, SAR

Edouard Evangelisti
contact affiliation	Université Côte d'Azur
contact email	edouard.evangelisti@inrae.fr
lab head
Edouard Evangelisti
contact affiliation	Université Côte d'Azur
contact email	edouard.evangelisti@inrae.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD056467
     1. Label: PRIDE project
     2. Name: Diversification of DIX domain-containing proteins in the SAR supergroup