PXD056438

PXD056438 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors
Description	This project explores the role of the chromatin remodelling complex in oligodendrogial development using a series of tools including conditional disruption of the INO80 gene within mice and primary oligodendrocyte precursors. This experiment sought to understand whether INO80 complex proteins interact with a major oligodendrocyte-specific transcription factor, OLIG2. OLIG2 was immuno-precipitated from cultured oligodendrocyte lineage cells differentiated from primary E13.5 cortical neural stem cells. Immunoprecipitated samples were then analysed for protein interaction partners via mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:23:59.467.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jordan Wright
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-02 00:32:30	ID requested
⏵ 1	2025-05-07 03:24:00	announced

Publication List

10.1002/glia.70006;
Wright JL, Jiang Y, Nayar SG, Li H, Richardson WD, The INO80 Chromatin Remodeling Complex Regulates Histone H2A.Z Mobility and the G1-S Transition in Oligodendrocyte Precursors. Glia, 73(6):1307-1323(2025) [pubmed]

10.1002/glia.70006;

Wright JL, Jiang Y, Nayar SG, Li H, Richardson WD, The INO80 Chromatin Remodeling Complex Regulates Histone H2A.Z Mobility and the G1-S Transition in Oligodendrocyte Precursors. Glia, 73(6):1307-1323(2025) [pubmed]

Keyword List

submitter keyword: INO80
Oligodendrocytes
H2A.Z
Chromatin remodelling complex
OLIG2

submitter keyword: INO80

Oligodendrocytes

H2A.Z

Chromatin remodelling complex

OLIG2

Contact List

Jordan L Wright
contact affiliation	Murdoch Children's Research Institute, Melbourne, VIC, Australia
contact email	jordan.wright@mcri.edu.au
lab head
Jordan Wright
contact affiliation	Murdoch Children's Research Institute
contact email	jordan.wright@mcri.edu.au
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD056438
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD056438

PRIDE project URI

Repository Record List

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