PXD056435

PXD056435 is an original dataset announced via ProteomeXchange.

Title	The potential link between inflammatory protein markers in stool samples of children with Autism Spectrum Disorder and their sibling
Description	Autism spectrum disorder is classified as a complex developmental disorder. Recent studies have shown that risk factors for ASD are both genetic and environmental. In our study, we aimed to determine whether inflammatory factors in the stool of children with ASD differ from their siblings.Our study population consisted of 57 children with ASD (48 boys/9 girls) and 57 healthy children (29 boys/28 girls) being their siblings. The mean age did not differ significantly between the ASD (10.4 ± 3.5 years) and control (9.0 ± 3.6 years) groups (median Q1, Q3 7.9 -13.0 years and 6.4 – 11.2 years). The average age difference between the groups was 1.34 ± 3.49 years. The aim of this study was to assess the gut immune status of children with ASD, through comparative measurement of A1AT, IgA and Cal in stool samples from children with ASD with sex- and age-matched sibling control group, with focus on ASD severity. The ratios of IgA1/IgA2 and S100A8/S100A9 were compared between moderate and severe forms on the basis of the CARS rating scale.Children with ASD had higher IgA, lower A1AT-1 and higher Cal levels. The calculated ratio of IgA1/IgA2 for moderate impairment group is higher than for severe group, despite the differences not being statistically significant. The ratio of S100A8/S100A9 does not differ statistically significant. Statistical significance level at p = 0.05Different patterns of protein marker levels observed based on severity of ASD could indicate different mechanisms underpinning GI issue comorbidity and warrants further investigation across the spectrum of ASD.
HostingRepository	PanoramaPublic
AnnounceDate	2025-09-15
AnnouncementXML	Submission_2025-09-15_16:58:18.860.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Veronika Vidova
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	6495B Triple Quadrupole LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-01 15:49:18	ID requested
⏵ 1	2025-09-15 16:58:19	announced

no publication

submitter keyword: Autism spectrum disorder, Immunoglubulin A, Alpha-1-antitrypsin, Calprotectin, stool samples, siblings

Elliott J. Price
contact affiliation	Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ)
contact email	elliott.james.price@gmail.com
lab head
Veronika Vidova
contact affiliation	Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ)
contact email	veronika.vidova@recetox.muni.cz
dataset submitter

Panorama Public dataset URI