PXD056374

PXD056374 is an original dataset announced via ProteomeXchange.

Title	Plasma IgG glycosylation profiling reveals the biological features of early COPD
Description	Chronic inflammatory and immune dysregulation are critical drivers in the development and progression of chronic obstructive pulmonary disease (COPD). Posttranslational modifications, such as glycosylation of Immunoglobulin G (IgG), modulates systemic inflammatory homeostasis. This study aims to profile plasma IgG glycopeptides (IgGPs) in COPD patients to uncover new insights into its pathogenesis and to identify novel biomarkers. Plasma IgG N-glycopeptides from 90 COPD patients, 45 clinical defined early COPD (CECOPD) patients and 90 healthy individuals were analyzed using an integrated platform that combines Fe3O4@PDA@DETA nanospheres enrichment with high-resolution mass spectrometry measurement. Correlations between IgG N-glycoforms and clinical parameters were assessed to explore underlying mechanisms of COPD progression. Disease-specific IgGPs were identified in both ECOPD and COPD cohorts. Notably, IgG glyco-pattern, rather than IgG levels, changed with disease progression. Early COPD patients showed decreased bisection and increased site-specific afucosylated galactosylation and fucosylation of IgG, indicating an anti-inflammatory state. In contrast, COPD patients gave increased inflammation, characterized by reduced galactosylation and sialylation. Interestingly, a subset of healthy controls displayed IgGPs patterns similar to early COPD, possibly reflecting the impact of substantial smoking exposure and associated immune responses. These findings suggest that plasma IgG glycosylation could serve as a potential biomarker for early COPD diagnosis, providing valuable insights into immune system changes during disease progression.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:19:47.460.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinyu Zhou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	complex glycosylation
Instrument	Bruker Daltonics solarix series

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-30 02:43:32	ID requested
⏵ 1	2025-05-07 03:19:49	announced

10.1021/acs.jproteome.4c00819;

Zhou J, Tan Y, Wu W, Chen J, Hu H, Yin Z, Liu S, Liu C, Qin X, Hu J, Wang Q, Luo L, Liu B, Wang Y, Zhang P, Miao J, Sun W, Yang L, Zhao H, Wang J, Wang L, Wang C, Plasma IgG Glycosylation Profiling Reveals the Biological Features of Early Chronic Obstructive Pulmonary Disease. J Proteome Res, 24(4):1804-1816(2025) [pubmed]

submitter keyword: IgG

COPD

glycosylation

chronic inflammation

mass spectrometry

Lin Wang
contact affiliation	State Key Laboratory of Common Mechanism Research for Major Disease, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
contact email	linwang@ibms.pumc.edu.cn
lab head
Jinyu Zhou
contact affiliation	Institute of Basic Medical Sciences
contact email	zhoujinyu@ibms.pumc.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD056374
     1. Label: PRIDE project
     2. Name: Plasma IgG glycosylation profiling reveals the biological features of early COPD