PXD056278 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MS-based analysis of the interacting proteins of human topoisomerases (TOP3A, TOP3B) |
| Description | In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several of the identitified binding proteins for each topoisomerase were validated by further experiments. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:41:55.025.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yun Xiong |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-25 22:48:38 | ID requested | |
| ⏵ 1 | 2025-11-16 16:41:56 | announced | |
Publication List
| Zhang H, Xiong Y, Chen Z, Chen J, Proteomic Analysis of Human Topoisomerases Reveals Their Distinct and Diverse Cellular Functions. Mol Cell Proteomics, 24(11):101082(2025) [pubmed] |
| 10.1016/j.mcpro.2025.101082; |
Keyword List
| submitter keyword: mass spectrometry, protein interaction, human,Proteomics, topoisomerases |
Contact List
| Junjie Chen |
|---|
| contact affiliation | Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA |
| contact email | yxiong3@mdanderson.org |
| lab head | |
| Yun Xiong |
|---|
| contact affiliation | UT. MD. Anderson Cancer Center |
| contact email | yxiong3@mdanderson.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD056278 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056278
- Label: PRIDE project
- Name: MS-based analysis of the interacting proteins of human topoisomerases (TOP3A, TOP3B)
