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PXD056270

PXD056270 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMigrions, a Migrasome-mediated unit for Intercellular Viral Transmission
DescriptionEfficient intercellular virus spread significantly contributes to overall pathogenesis and virulence. Our study reveals that viral RNAs and proteins are transported to migrasomes during cell migration. This chimera of migrasomes and virions, termed Migrion, demonstrates infectivity, resulting in greater infection efficiency compared to free virus particles. Moreover, the clustered packaging of viral components by Migrion facilitated the collective transfer and replication of multiple viral nucleic acids within single recipient cells. Mechanistically, endocytosis, endosomal acidification and content release is essential for Migrion infection. Migrion represents a novel mode of viral transmission among cells, which couples viral transmission with cell migration, adding another piece to the puzzle of viral spreading mechanisms.
HostingRepositoryiProX
AnnounceDate2024-09-25
AnnouncementXMLSubmission_2024-09-25_20:16:18.582.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaohao Tang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-25 20:15:36ID requested
12024-09-25 20:16:19announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Migrions,Intercellular Viral Transmission
Contact List
Yang Chen
contact affiliationPeking University Health Science Center
contact emailchenyang1816185048@bjmu.edu.cn
lab head
Haohao Tang
contact affiliationPeking University Health Science Center
contact emailTanghaohao0987@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI