PXD056265

PXD056265 is an original dataset announced via ProteomeXchange.

Title	Proteomic study of amnestic mild cognitive impairment
Description	Amnestic MCI is often considered an early clinical stage of AD, but its subtle presentation leads to infrequent neurological evaluations. Early plasma biomarker screening during routine check-ups in community hospitals could enhance aMCI detection rates. Advances in proteomics, particularly mass spectrometry, have enabled the detection of low-abundance plasma proteins, opening new possibilities for aMCI biomarker identification. This study included 84 participants from the STAR cohort. We utilized deep plasma proteomics to detect low-abundance proteins, enriched with biofunctional magnetic beads. An early diagnostic model for aMCI was developed through bioinformatics and machine learning, with performance compared to the Simoa assay.
HostingRepository	iProX
AnnounceDate	2024-09-26
AnnouncementXML	Submission_2024-09-25_20:09:29.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hui Shan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-25 20:09:08	ID requested
⏵ 1	2024-09-25 20:09:30	announced

Dataset with its publication pending

submitter keyword: Alzheimer's disease, plasma proteomics, mass spectrometry

Yuxin Yin
contact affiliation	Peking University Shenzhen Hospital
contact email	yinyuxin@bjmu.edu.cn
lab head
Hui Shan
contact affiliation	Peking University Shenzhen Hospital
contact email	shanhui_90@163.com
dataset submitter

iProX dataset URI