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PXD056264

PXD056264 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInhibition of osteosarcoma progression by sporoderm-removed ganoderma lucidum spores
DescriptionOsteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action. Our in vivo and in vitro experiments showed that RGLS significantly inhibited S-180 OS cell proliferation, colony formation, and migration, while simultaneously inducing apoptosis. Multi-omics analysis revealed that RGLS disrupted glycerophospholipid metabolism by upregulating lysophosphatidylcholine (LysoPC) levels through phospholipase A2 (PLA2)-mediated pathways. Co-culture assays further demonstrated that RGLS promoted the endocytosis of macrophage-derived Pla2g7 protein into S-180 cells, enhancing its anti-cancer effects. Additionally, RGLS modulated the cellular fatty acid profile and suppressed the β-oxidation of long-chain fatty acids, leading to energy depletion in OS cells. These findings provide a novel view of the multi-targeted mechanisms of RGLS, positioning it as a promising candidate for OS therapy.
HostingRepositoryiProX
AnnounceDate2024-09-25
AnnouncementXMLSubmission_2024-09-25_19:00:59.479.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMengyao Wang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-25 19:00:39ID requested
12024-09-25 19:00:59announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Sporoderm-removed Ganoderma lucidum spores, Osteosarcoma
Contact List
Jihong Yang
contact affiliationBoYu Intelligent Health Innovation Laboratory
contact emailyangdataever@163.com
lab head
Mengyao Wang
contact affiliationBoYu Intelligent Health Innovation Laboratory
contact emailwangmy2022@gmail.com
dataset submitter
Full Dataset Link List
iProX dataset URI