PXD056264
PXD056264 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Inhibition of osteosarcoma progression by sporoderm-removed ganoderma lucidum spores |
Description | Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action. Our in vivo and in vitro experiments showed that RGLS significantly inhibited S-180 OS cell proliferation, colony formation, and migration, while simultaneously inducing apoptosis. Multi-omics analysis revealed that RGLS disrupted glycerophospholipid metabolism by upregulating lysophosphatidylcholine (LysoPC) levels through phospholipase A2 (PLA2)-mediated pathways. Co-culture assays further demonstrated that RGLS promoted the endocytosis of macrophage-derived Pla2g7 protein into S-180 cells, enhancing its anti-cancer effects. Additionally, RGLS modulated the cellular fatty acid profile and suppressed the β-oxidation of long-chain fatty acids, leading to energy depletion in OS cells. These findings provide a novel view of the multi-targeted mechanisms of RGLS, positioning it as a promising candidate for OS therapy. |
HostingRepository | iProX |
AnnounceDate | 2024-09-25 |
AnnouncementXML | Submission_2024-09-25_19:00:59.479.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mengyao Wang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-09-25 19:00:39 | ID requested | |
⏵ 1 | 2024-09-25 19:00:59 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Sporoderm-removed Ganoderma lucidum spores, Osteosarcoma |
Contact List
Jihong Yang | |
---|---|
contact affiliation | BoYu Intelligent Health Innovation Laboratory |
contact email | yangdataever@163.com |
lab head | |
Mengyao Wang | |
contact affiliation | BoYu Intelligent Health Innovation Laboratory |
contact email | wangmy2022@gmail.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |