PXD056258

PXD056258 is an original dataset announced via ProteomeXchange.

Title	Discovery of biomarker proteins in plasma extracellular vesicles from septic patients
Description	Sepsis is a life-threatening condition induced by a dysregulated host response to infection, characterized clinically by systemic inflammation, hemodynamic instability, organ dysfunction, and high mortality. Plasma-derived extracellular vesicles (EVs) have been reported to play a role in mediating pathophysiological responses in sepsis, such as inflammation and coagulation. This study aims to identify biomarkers and elucidate pathways through differentially expressed proteins from plasma-derived EVs in septic patients.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_18:50:18.694.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	chanhyun na
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-25 13:22:58	ID requested
⏵ 1	2025-07-13 18:50:19	announced

10.1038/s41598-025-06430-x;

Park C, Ryu T, Mohamed-Hinds R, Kim K, Kim JH, Zou L, Williams B, Na CH, Chao W, Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. Sci Rep, 15(1):21871(2025) [pubmed]

submitter keyword: proteomics, mass spectrometry, plasma-derived extracellular vesicles (EVs),Sepsis, tandem mass tag (TMT), biomarker

Chan Hyun Na
contact affiliation	Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
contact email	chanhyun@jhmi.edu
lab head
chanhyun na
contact affiliation	Johns Hopkins University
contact email	chanhyun.na@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD056258

PRIDE project URI

• PRIDE
  1. PXD056258
     1. Label: PRIDE project
     2. Name: Discovery of biomarker proteins in plasma extracellular vesicles from septic patients