PXD056251

PXD056251 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Global acetylomic changes induced by HDAC10 inhibitor in acute lymphoid leukemia cells
Description	A SILAC-based quantitative acetylomics experiment was performed to study the changes in lysine acetylation status induced by the HDAC10 inhibitor PZ48 in RS4-11 acute lymphoid leukemia cells.
HostingRepository	PRIDE
AnnounceDate	2025-06-01
AnnouncementXML	Submission_2025-06-01_09:10:51.510.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jia-Xuan Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-25 10:00:00	ID requested
⏵ 1	2025-06-01 09:10:52	announced

Publication List

10.1038/s41375-025-02612-8;
Mieland AO, Petrosino G, Dejung M, Chen JX, Fulzele A, Mahmoudi F, Tu JW, Mustafa AM, Zeyn Y, Hieber C, Bros M, Schn, ö, der TM, Heidel FH, Najafi S, Oehme I, Hofmann I, Schutkowski M, Hilscher S, Kosan C, Butter F, Bhatia S, Sippl W, Kr, ä, mer OH, The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells. Leukemia, ():(2025) [pubmed]

10.1038/s41375-025-02612-8;

Mieland AO, Petrosino G, Dejung M, Chen JX, Fulzele A, Mahmoudi F, Tu JW, Mustafa AM, Zeyn Y, Hieber C, Bros M, Schn, ö, der TM, Heidel FH, Najafi S, Oehme I, Hofmann I, Schutkowski M, Hilscher S, Kosan C, Butter F, Bhatia S, Sippl W, Kr, ä, mer OH, The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells. Leukemia, ():(2025) [pubmed]

Keyword List

submitter keyword: LC-MS,Lysine acetylation, HDAC10, Acute lymphoid leukemia

submitter keyword: LC-MS,Lysine acetylation, HDAC10, Acute lymphoid leukemia

Contact List

Oliver Krämer
contact affiliation	Universitätsmedizin Mainz, Germany
contact email	okraemer@uni-mainz.de
lab head
Jia-Xuan Chen
contact affiliation	Institute of Molecular Biology
contact email	j.chen@imb-mainz.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD056251
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD056251

PRIDE project URI

Repository Record List

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