PXD056166

PXD056166 is an original dataset announced via ProteomeXchange.

Title	Expanded characterization and localization of male seminal fluid proteins within the female reproductive tract of the dengue vector mosquito Aedes aegypti
Description	Aedes aegypti mosquitoes transmit numerous viruses that adversely impact human health and contemporary biological control programs aim to reduce fertility despite our limited understanding of interactions between the sexes required for reproduction. During mating, males transfer seminal fluid proteins (SFPs) to females which alter female post-mating behavior, physiology and gene regulation but little is known about the individual Aedes SFPs that contribute to fertility. In Drosophila, a small subset of SFPs persist and localize to the sperm storage organs and oviduct or enter the hemolymph which suggests the participation in specific post-mating processes. Here, we used a mass spectrometry-based proteomics, in conjunction with whole animal heavy labelling, to expand the characterization of Ae. aegypti ejaculate proteins (sperm and SFPs) transferred to females.
HostingRepository	PRIDE
AnnounceDate	2026-06-24
AnnouncementXML	Submission_2026-06-24_04:06:10.384.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	steve dorus
SpeciesList	scientific name: Aedes aegypti aegypti; NCBI TaxID: NEWT:1424507;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-24 05:06:06	ID requested
⏵ 1	2026-06-24 04:06:10	announced

10.1016/j.jprot.2025.105410;

10.1016/J.JPROT.2025.105410;

submitter keyword: fertility, mass spectrometry, mating, sperm, accessory gland,proteome, reproduction

Steve Dorus
contact affiliation	Center for Reproductive Evolution, Syracuse University
contact email	sdorus@syr.edu
lab head
steve dorus
contact affiliation	Syracuse University
contact email	sdorus@syr.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD056166

PRIDE project URI

• PRIDE
  1. PXD056166
     1. Label: PRIDE project
     2. Name: Expanded characterization and localization of male seminal fluid proteins within the female reproductive tract of the dengue vector mosquito Aedes aegypti