PXD056148

PXD056148 is an original dataset announced via ProteomeXchange.

Title	Interacting proteins of BDH1 in heart by IP LC-MS/MS
Description	Sepsis-induced myocardial dysfunction is associated with high mortality in sepsis. However, the underlying mechanisms of sepsis-induced myocardial dysfunction remain unclear. The heart is an energy-demanding organ. Under basal physiological conditions, cardiomyocytes rely primarily on energy provided by fatty acid oxidation. However, recent studies have revealed the important role of metabolic rearrangements in cardiomyocytes under some pathological conditions. 3-hydroxybutyrate dehydrogenase 1 (BDH1) is a key enzyme in ketone body metabolism, catalyzing the interconversion of acetoacetate and (R)-3-hydroxybutyrate. Previous studies have demonstrated the role of BDH1 in myocardial metabolic remodeling during acute fasting, but the expression patterns and functions of BDH1 in the septic heart are unknown. The aim of this study was to identify the interactors of BDH1 in H9C2 rat cardiomyocytes with or without lipopolysaccharide (LPS) treatment.
HostingRepository	iProX
AnnounceDate	2024-09-19
AnnouncementXML	Submission_2024-09-24_00:36:51.911.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tiening Zhang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	(2S,3S,4R)-3,4-dihydroxyisoleucine
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-24 00:36:40	ID requested
⏵ 1	2024-09-24 00:36:52	announced

Dataset with its publication pending

submitter keyword: BDH1,IP LC-MS/MS, cardiomyocyte

Tiening Zhang
contact affiliation	Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
lab head
Tiening Zhang
contact affiliation	Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
dataset submitter

iProX dataset URI