<<< Full experiment listing

PXD056148

PXD056148 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInteracting proteins of BDH1 in heart by IP LC-MS/MS
DescriptionSepsis-induced myocardial dysfunction is associated with high mortality in sepsis. However, the underlying mechanisms of sepsis-induced myocardial dysfunction remain unclear. The heart is an energy-demanding organ. Under basal physiological conditions, cardiomyocytes rely primarily on energy provided by fatty acid oxidation. However, recent studies have revealed the important role of metabolic rearrangements in cardiomyocytes under some pathological conditions. 3-hydroxybutyrate dehydrogenase 1 (BDH1) is a key enzyme in ketone body metabolism, catalyzing the interconversion of acetoacetate and (R)-3-hydroxybutyrate. Previous studies have demonstrated the role of BDH1 in myocardial metabolic remodeling during acute fasting, but the expression patterns and functions of BDH1 in the septic heart are unknown. The aim of this study was to identify the interactors of BDH1 in H9C2 rat cardiomyocytes with or without lipopolysaccharide (LPS) treatment.
HostingRepositoryiProX
AnnounceDate2024-09-19
AnnouncementXMLSubmission_2024-09-24_00:36:51.911.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTiening Zhang
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList(2S,3S,4R)-3,4-dihydroxyisoleucine
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-24 00:36:40ID requested
12024-09-24 00:36:52announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: BDH1,IP LC-MS/MS, cardiomyocyte
Contact List
Tiening Zhang
contact affiliationShengjing Hospital of China Medical University
contact emailcmuztn@vip.qq.com
lab head
Tiening Zhang
contact affiliationShengjing Hospital of China Medical University
contact emailcmuztn@vip.qq.com
dataset submitter
Full Dataset Link List
iProX dataset URI