PXD056084

PXD056084 is an original dataset announced via ProteomeXchange.

Title	Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes
Description	We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alkyne-tagged conidiogenone C-derived probe.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_02:48:00.581.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Tian
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-23 04:12:18	ID requested
⏵ 1	2025-05-07 02:48:01	announced

10.1038/s41467-024-55189-8;

Li T, Jiang S, Dai Y, Wu X, Guo H, Shi L, Sang X, Ren L, Wang J, Shi L, Zhou W, Li H, Hao HD, Total synthesis and target identification of marine cyclopiane diterpenes. Nat Commun, 15(1):10851(2024) [pubmed]

submitter keyword: conidiogenone C

Li houhua
contact affiliation	State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, School of Pharmaceutical Sciences, Peking University
contact email	lihouhua@pku.edu.cn
lab head
Li Tian
contact affiliation	Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	litian@imm.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD056084

PRIDE project URI

• PRIDE
  1. PXD056084
     1. Label: PRIDE project
     2. Name: Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes