PXD056064

PXD056064 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne
Description	This study utilizes cysteine chemoproteomics paired with a high-throughput structure-guided in silico approach towards assessing structural motifs of cysteines that are highly reactive towards iodoacetamide alkyne (IAA).
HostingRepository	PRIDE
AnnounceDate	2025-10-13
AnnouncementXML	Submission_2025-10-12_16:18:00.847.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lisa Boatner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	biotinylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-20 17:55:56	ID requested
⏵ 1	2025-10-12 16:18:01	announced

Publication List

10.1021/acschembio.5c00225;
Boatner LM, Eberhardt J, Shikwana F, Holcomb M, Lee P, Houk KN, Forli S, Backus KM, CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne. ACS Chem Biol, 20(7):1669-1682(2025) [pubmed]

10.1021/acschembio.5c00225;

Boatner LM, Eberhardt J, Shikwana F, Holcomb M, Lee P, Houk KN, Forli S, Backus KM, CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne. ACS Chem Biol, 20(7):1669-1682(2025) [pubmed]

Keyword List

submitter keyword: reactivity,cysteine, chemoproteomics, isoTOP-ABPP

submitter keyword: reactivity,cysteine, chemoproteomics, isoTOP-ABPP

Contact List

Keriann Marie Backus
contact affiliation	Biological Chemistry, UCLA, California, United States
contact email	kbackus@mednet.ucla.edu
lab head
Lisa Boatner
contact affiliation	The University of California, Los Angeles
contact email	lisaboatner@g.ucla.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD056064
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD056064

PRIDE project URI

Repository Record List

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