PXD055986

PXD055986 is an original dataset announced via ProteomeXchange.

Title	Proteomic and metabolomic profiling in human peripartum cardiomyopathy
Description	Pregnancy imposes significant cardiovascular adaptations including progressive increases in plasma volume and cardiac output. For most women, this physiological adaptation resolves at the end of pregnancy, but some women develop pathological dilatation and ultimately heart failure late in pregnancy or in the postpartum period manifesting as peripartum cardiomyopathy (PPCM). Despite the mortality risk of this form of heart failure, the molecular mechanisms underlying PPCM have not been extensively examined in human hearts. We examined protein and metabolite expression in PPCM compared to familial dilated cardiomyopathy (DCM) and non-failing donors using unbiased quantitative mass spectrometry. Proteomics analysis identified uniquely downregulated proteins, such as SBSPON and TNS3, in PPCM relative to both DCM and donors. KEGG analysis of PPCM proteins identified key pathways associated with intracellular signalling cascades, protein folding and neurohormonal pathways that can directly impact the contractility of the heart. Metabolomics demonstrated uniquely expressed metabolites, such as upregulated homogentisate and deoxycholate, and downregulated lactate and alanine, along with reduced alanine, aspartate and glutamate metabolism are involved in the PPCM phenotype. Therefore, this study is the first to isolate unique molecular features underlying PPCM at the protein and metabolite level which may hold promise as future therapeutic candidate targets.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_04:18:37.428.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David James
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-18 08:25:46	ID requested
⏵ 1	2025-05-07 04:18:38	announced

10.1161/circheartfailure.124.011725;

Li A, Fang B, Li M, Koay YC, Malecki C, Hunter B, Harney D, Dos Remedios CG, Larance M, O'Sullivan JF, Lal S, Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy. Circ Heart Fail, 17(12):e011725(2024) [pubmed]

submitter keyword: heart, multi-omics, pregnancy, metabolome, peripartum cardiomyopathy,human, proteome

Sean Lal
contact affiliation	Clinical Academic Cardiologist Associate Professor, Medicine and Medical Sciences University of Sydney & Royal Prince Alfred Hospital
contact email	sean.lal@sydney.edu.au
lab head
David James
contact affiliation	The University of Sydney
contact email	david.james@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055986

PRIDE project URI

• PRIDE
  1. PXD055986
     1. Label: PRIDE project
     2. Name: Proteomic and metabolomic profiling in human peripartum cardiomyopathy