PXD055926 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Simple , Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes |
| Description | Herein we describe a new enantioselective route for the synthesis of all stereoisomers of 2,3-disubstituted azetidines. This approach uses simple strain release functionalization of preformed 1-azabicyclobutanes (ABBs), which enables installation of a wide array of nucleophiles at the C3-position. Chemical proteomic profiling of stereoisomeric sets of cysteine-reactive acrylamides derived from the new azetidine library reveals ligandable protein sites distinct from those of azetidine probes synthesized using C–H arylation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:37:01.832.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hayden Sharma |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-16 22:06:43 | ID requested | |
| ⏵ 1 | 2026-06-28 16:37:02 | announced | |
Publication List
| Bielecki M, Nassir M, Sharma HA, Truax NJ, Raheja N, Thompson TM, El-Hayek Ewing T, Melillo B, Cravatt BF, Baran PS, Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes. J Am Chem Soc, 147(25):22209-22218(2025) [pubmed] |
| 10.1021/jacs.5c07227; |
Keyword List
| submitter keyword: chemical synthesis,Proteomics, covalent probes, chemical biology |
Contact List
| Dr. Benjamin F. Cravatt |
|---|
| contact affiliation | Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA (lab head) |
| contact email | cravatt@scripps.edu |
| lab head | |
| Hayden Sharma |
|---|
| contact affiliation | Scripps Research |
| contact email | hsharma@scripps.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD055926 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055926
- Label: PRIDE project
- Name: Simple , Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes
