PXD055922

PXD055922 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Lactylation of Tau in Human Alzheimers Disease Brain
Description	Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysine residues known as lactylation. Our findings suggest that tau lactylation links metabolic dysregulation with tauopathies and could serve as a novel diagnostic and therapeutic target.
HostingRepository	MassIVE
AnnounceDate	2025-03-20
AnnouncementXML	Submission_2025-03-20_13:18:44.696.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michaella Rekowski
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Phospho; Carbamidomethyl; Carboxyethyl
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-16 19:05:04	ID requested
⏵ 1	2025-03-20 13:18:45	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: lactylation, Alzheimers disease, tau, tauopathy

submitter keyword: lactylation, Alzheimers disease, tau, tauopathy

Contact List

Ning Wang
contact affiliation	University of Kansas Medical Center
contact email	nwang2@kumc.edu
lab head
Michaella Rekowski
contact affiliation	University of Kansas Medical Center
contact email	mrekowski@kumc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095881/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095881/