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PXD055894

PXD055894 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17
DescriptionOne of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large proportion of the population, due to complete gene deletion. We defined the impact of a UGT2B17 deficiency on the proteome of normal human liver tissues by data-independent acquisition mass spectrometry.
HostingRepositoryMassIVE
AnnounceDate2025-04-11
AnnouncementXMLSubmission_2025-04-11_11:11:21.830.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichele Rouleau
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListMet-loss; methionine oxidation with neutral loss of 80 Da; methionine oxidation with neutral loss of 64 Da; S-carboxamidomethyl-L-cysteine
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-16 06:04:47ID requested
12025-04-11 11:11:22announced
Publication List
no publication
Keyword List
submitter keyword: DIAnn, Liver proteomics, Glycosyltransferase, UGT2B17, Germline gene deletion
Contact List
Chantal Guillemette
contact affiliationCHU de Quebec Research Center - Universite Laval
contact emailchantal.guillemette@crchudequebec.ulaval.ca
lab head
Michele Rouleau
contact affiliationCHU de Qu�bec Research center
contact emailmichele.rouleau@crchudequebec.ulaval.ca
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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