PXD055894
PXD055894 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17 |
Description | One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large proportion of the population, due to complete gene deletion. We defined the impact of a UGT2B17 deficiency on the proteome of normal human liver tissues by data-independent acquisition mass spectrometry. |
HostingRepository | MassIVE |
AnnounceDate | 2025-04-11 |
AnnouncementXML | Submission_2025-04-11_11:11:21.830.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michele Rouleau |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Met-loss; methionine oxidation with neutral loss of 80 Da; methionine oxidation with neutral loss of 64 Da; S-carboxamidomethyl-L-cysteine |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-09-16 06:04:47 | ID requested | |
⏵ 1 | 2025-04-11 11:11:22 | announced |
Publication List
no publication |
Keyword List
submitter keyword: DIAnn, Liver proteomics, Glycosyltransferase, UGT2B17, Germline gene deletion |
Contact List
Chantal Guillemette | |
---|---|
contact affiliation | CHU de Quebec Research Center - Universite Laval |
contact email | chantal.guillemette@crchudequebec.ulaval.ca |
lab head | |
Michele Rouleau | |
contact affiliation | CHU de Qu�bec Research center |
contact email | michele.rouleau@crchudequebec.ulaval.ca |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000095873/ |