PXD055894

PXD055894 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17
Description	One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large proportion of the population, due to complete gene deletion. We defined the impact of a UGT2B17 deficiency on the proteome of normal human liver tissues by data-independent acquisition mass spectrometry.
HostingRepository	MassIVE
AnnounceDate	2025-04-11
AnnouncementXML	Submission_2025-04-11_11:11:21.830.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michele Rouleau
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Met-loss; methionine oxidation with neutral loss of 80 Da; methionine oxidation with neutral loss of 64 Da; S-carboxamidomethyl-L-cysteine
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-16 06:04:47	ID requested
⏵ 1	2025-04-11 11:11:22	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: DIAnn, Liver proteomics, Glycosyltransferase, UGT2B17, Germline gene deletion

submitter keyword: DIAnn, Liver proteomics, Glycosyltransferase, UGT2B17, Germline gene deletion

Contact List

Chantal Guillemette
contact affiliation	CHU de Quebec Research Center - Universite Laval
contact email	chantal.guillemette@crchudequebec.ulaval.ca
lab head
Michele Rouleau
contact affiliation	CHU de Qu�bec Research center
contact email	michele.rouleau@crchudequebec.ulaval.ca
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000095873/