PXD055857

PXD055857 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomic analysis of induced neurons from patients with Huntington’s disease
Description	Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial to the expression of the disease clinically. Here we generated induced neurons (iNs) through direct reprogramming of skin fibroblasts from HD-patients. This resulted in the generation of patient-derived HD neurons that retained age-dependent epigentic characteristics of the donors. Using these cells, we then undertook proteomic and phosphoproteomic analyses.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:29:41.811.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD055857
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Melinda Rezeli
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-13 14:45:43	ID requested
⏵ 1	2026-09-06 16:29:42	announced

Danics L, Muralidharan C, Varga Á, Rezeli M, Gil J, Abbas AA, Pap Á, Park AS, Cserhalmi M, Legault EM, S, ő, th Á, Jamniczky D, Zsoldos R, Barker RA, R, ó, na G, Drouin-Ouellet J, Mark, ó, -Varga G, Darula Z, Pircs K, Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons. Cell Mol Biol Lett, 31(1):(2026) [pubmed]

10.6019/PXD055857;

10.1186/s11658-026-00948-2;

submitter keyword: induced neurons,Huntington disease

Johan Jakobsson
contact affiliation	Dept of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
contact email	johan.jakobsson@med.lu.se
lab head
Melinda Rezeli
contact affiliation	Lund University
contact email	melinda.rezeli@bme.lth.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD055857

PRIDE project URI

• PRIDE
  1. PXD055857
     1. Label: PRIDE project
     2. Name: Phosphoproteomic analysis of induced neurons from patients with Huntington’s disease