PXD055810
PXD055810 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Neutrophils display novel cytosolic proliferating cell nuclear antigen (PCNA) partners involved in interferon response in COVID-19 |
| Description | Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection, exhibiting features of deregulation and reprogramming. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and known to interact with numerous proteins that regulate neutrophil survival, NADPH oxidase-dependent reactive oxygen species (ROS) production, and cell energy metabolism. In this sense this study aimed to examine the cytosolic protein content and PCNA interactome in neutrophils from COVID-19 patients. Methods: Proteomics analysis was performed on neutrophil cytosols from healthy donors and patients with severe or critical COVID-19. In vitro approaches with ultrapure neutrophils were employed to validate the role of PCNA dynamics in neutrophil overactivation during COVID-19. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-07 |
| AnnouncementXML | Submission_2025-05-07_03:13:59.995.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD055810 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Johana Chicher |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-09-12 02:49:29 | ID requested | |
| ⏵ 1 | 2025-05-07 03:14:00 | announced |
Publication List
| 10.6019/PXD055810; |
| 10.1159/000543633; |
| Pesenti L, de Oliveira Formiga R, Tamassia N, Gardiman E, Chable de La H, é, ronni, è, re F, Gasperini S, Chicher J, Kuhn L, Hammann P, Le Gall M, Saraceni-Tasso G, Martin C, Hosmalin A, Breckler M, Herv, é R, Decker P, Ladjemi MZ, P, è, ne F, Burgel PR, Cassatella MA, Witko-Sarsat V, Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients. J Innate Immun, 17(1):154-175(2025) [pubmed] |
Keyword List
| submitter keyword: interferon,Neutrophils, neutrophils extracellular traps, COVID-19, PCNA |
Contact List
| Véronique Witko-Sarsat | |
|---|---|
| contact affiliation | INSERM U1016, Institut Cochin, Université Paris Cité, CNRS 8104, Paris, France |
| contact email | veronique.witko@inserm.fr |
| lab head | |
| Johana Chicher | |
| contact affiliation | Université de Strasbourg, Plateforme Protéomique Strasbourg-Esplanade, Centre National de la Recherche Scientifique |
| contact email | j.chicher@ibmc-cnrs.unistra.fr |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055810 |
| PRIDE project URI |
Repository Record List
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