PXD055799

PXD055799 is an original dataset announced via ProteomeXchange.

Title	Aromatase-encoding gene CYP19A1 reduces sperm motility by down-regulating ATP synthesis related gene expression in seminal plasma extracellular vesicles
Description	Aromatase is the rate limiting enzyme in estrogen biosynthesis encoded by the CYP19A1 gene, and excessive aromatase can reduce the semen quality of roosters. Seminal plasma extracellular vesicles are tiny membrane vesicles that can carry and transmit signaling molecules, thereby affecting semen quality. It is still unclear whether aromatase affects the semen quality through SPEV. In this study, we injected lentivirus carrying CYP19A1 gene over-expression vector into the testis of 35 -week-old roosters and measured semen quality, serum and seminal plasma T and E2 levels. Subsequently, we isolated seminal plasma extracellular vesicles and performed proteomic sequencing, aiming to reveal the molecular mechanisms of aromatase mediated seminal plasma extracellular vesicles regulation of rooster semen quality.
HostingRepository	iProX
AnnounceDate	2024-09-12
AnnouncementXML	Submission_2025-01-09_23:19:38.396.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuliang Luo
SpeciesList	scientific name: Gallus gallus; NCBI TaxID: 9031;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-11 20:51:22	ID requested
⏵ 1	2025-01-09 23:19:38	announced

Dataset with its publication pending

submitter keyword: roosters, aromatase, CYP19A1, extracellular vesicles, sperm motility

Yanzhang Gong
contact affiliation	Huazhong Agricultural University
contact email	1958136961@qq.com
lab head
Xuliang Luo
contact affiliation	Huazhong Agricultural University
contact email	Luoxuliang@webmail.hzau.edu.cn
dataset submitter

iProX dataset URI