PXD055639

PXD055639 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Colorectal cancer Circulating tumor cells released Extracelluar Vesicles proteome cargo analysis
Description	Background: Circulating tumor cells (CTCs) play a key role in cancer progression, and in vitro CTC models are essential for studying their biology. This study examined extracellular vesicles (EVs) from CTC lines of a metastatic colorectal cancer (mCRC) patient who progressed despite therapy. Methods and results: EVs from different CTC lines showed size and morphological variations. Proteomic analysis revealed an enrichment of proteins linked to stemness, endosomal biogenesis, and mCRC prognosis. Integrins were notably enriched in EVs from post-therapy CTC lines. In vivo, EVs accumulated in the liver, lungs, kidneys, and bones, though their influence on CTC organotropism was unclear. Conclusions: This study highlights therapy-related changes in EVs from mCRC CTCs and their role in cancer spread. These findings suggest the utility of CTC-derived EVs in understanding cancer dissemination, though further validation in mCRC patients is needed.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:41:19.157.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luis Enrique Cortes Hernandez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact II

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-06 09:50:13	ID requested
⏵ 1	2025-05-07 03:41:19	announced

Publication List

10.1186/s13046-025-03360-4;
Cort, é, s-Hern, á, ndez LE, Eslami-S Z, Attina A, Batista S, Cayrefourcq L, Vialeret J, Di Vizio D, Hirtz C, Costa-Silva B, Alix-Panabi, è, res C, Proteomic profiling and functional analysis of extracellular vesicles from metastasis-competent circulating tumor cells in colon cancer. J Exp Clin Cancer Res, 44(1):102(2025) [pubmed]

10.1186/s13046-025-03360-4;

Cort, é, s-Hern, á, ndez LE, Eslami-S Z, Attina A, Batista S, Cayrefourcq L, Vialeret J, Di Vizio D, Hirtz C, Costa-Silva B, Alix-Panabi, è, res C, Proteomic profiling and functional analysis of extracellular vesicles from metastasis-competent circulating tumor cells in colon cancer. J Exp Clin Cancer Res, 44(1):102(2025) [pubmed]

Keyword List

submitter keyword: extracellular vesicles,Colorectal cancer, Circulating tumor cells

submitter keyword: extracellular vesicles,Colorectal cancer, Circulating tumor cells

Contact List

Catherine Alix-Panabieres
contact affiliation	Head of the Laboratory of Rare Human Circulating Cells – University Medical Center of Montpellier – France
contact email	c-panabieres@chu-montpellier.fr
lab head
Luis Enrique Cortes Hernandez
contact affiliation	Laboratory of Rare Human Circulating Cells – University Medical Center of Montpellier – France
contact email	luis.e.cortes.hdz@gmail.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055639

PRIDE project URI

Repository Record List

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