PXD055635

PXD055635 is an original dataset announced via ProteomeXchange.

Title	Divergent molecular responses of bronchial human airway epithelium to SARS-CoV-2 infection in relation to pre-existing respiratory disease states
Description	The COVID-19 pandemic has revealed differences in individual susceptibility and severity, with pre-existing respiratory diseases as potential risk factors. Using an in vitro model of differentiated primary bronchial epithelial cells, we investigated the molecular mechanisms of SARS-CoV-2 infection in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Our study found that CF and COPD airway epithelium had reduced susceptibility to SARS-CoV-2 compared to healthy controls. This was linked to preserved epithelial integrity, lower viral replication, and attenuated antiviral and inflammatory responses. Mechanistically, we identified reduced TMPRSS2 activity as a contributing factor in CF epithelium. Importantly, the baseline upregulation of complement and inflammatory pathways in CF and COPD epithelium appeared to prime an antiviral state prior to infection. Analysis of a COVID-19 patient cohort validated our findings, showing correlations between specific inflammatory markers (CXCL-10, SERPINA1, and CFB) and SARS-CoV-2 infection severity. This study offers insights into SARS-CoV-2 pathogenesis and potential biomarkers for clinical monitoring.
HostingRepository	PRIDE
AnnounceDate	2025-02-12
AnnouncementXML	Submission_2025-02-12_05:15:23.553.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Viviane de Almeida Bastos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-06 08:58:26	ID requested
⏵ 1	2025-02-12 05:15:23	announced

10.1016/J.ISCI.2025.111999;

submitter keyword: SARS-CoV-2, cystic fibrosis,Lung, chronic obstrutive pulmonary diseases, infection

Loic Guillot
contact affiliation	Inserm UMR S 938, CRSA, Bât. Kourilsky, 34 Rue Crozatier, 75012 Paris, France.
contact email	loic.guillot@inserm.fr
lab head
Viviane de Almeida Bastos
contact affiliation	Sorbonne University
contact email	viviane.de_almeida_bastos@sorbonne-universite.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055635
     1. Label: PRIDE project
     2. Name: Divergent molecular responses of bronchial human airway epithelium to SARS-CoV-2 infection in relation to pre-existing respiratory disease states