PXD055629

PXD055629 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Functional genomics using high-throughput methods for salivary analysis in Sjögren's disease
Description	Primary Sjögren's disease (SjD) is a slow-progressing autoimmune disease that affects salivary and lacrimal glands, causing dry eyes (xerophthalmia) and dry mouth (xerostomia). Diagnosing SjD involves clinical, serological, and histological assessments, but reliable biomarkers are lacking. This study analysed the metabolic and proteomic profiles of 19 female SjD patients (based on ACR-EULAR criteria) compared to 20 healthy individuals. Saliva and blood samples were analysed using mass spectrometry and chromatography. Proteomic analysis was performed with the nanoElute nanoflow system coupled to a timsTof-Pro mass spectrometer, and metabolic profiling with a GC-TOF/MS Pegasus HT. Statistical tests identified significant differences in metabolites and proteins between SjD patients and controls. Metabolome analysis revealed changes in amino acid synthesis, purine and lipid metabolism, and exposure to external compounds. Proteomic analysis indicated immune-related proteins and inflammatory lipid metabolism. GNAI2, B2MG, NGAL, SLUR2, HS90, SODC, and A2GL emerged as potential biomarkers for SjD. This study demonstrates the potential of high-performance techniques in identifying biomarkers for SjD diagnosis and prognosis.
HostingRepository	PRIDE
AnnounceDate	2025-03-31
AnnouncementXML	Submission_2025-03-31_09:12:50.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giovanna Florezi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-06 05:28:27	ID requested
⏵ 1	2025-03-31 09:12:50	announced

Publication List

10.1111/ODI.15328;

10.1111/ODI.15328;

Keyword List

submitter keyword: Sjogren's syndrome
saliva
Proteomics
Metabolomics

submitter keyword: Sjogren's syndrome

saliva

Proteomics

Metabolomics

Contact List

Carlos Alberto
contact affiliation	Escola Superior de Agricultura Luiz de Queiroz da Universidade de São Paulo
contact email	calabate@usp.br
lab head
Giovanna Florezi
contact affiliation	Faculdade de Odontologia da Universidade de São Paulo
contact email	giovanna.florezi@usp.br
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD055629
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD055629

PRIDE project URI

Repository Record List

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