PXD055604 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serpina1e mediates the exercise-induced enhancement of hippocampal memory |
| Description | Although exercise improves cognition, the specific molecules responsible for these beneficial effects remain unclear. Here, we propose that the myokine Serpina1e acts as a molecular mediator for these effects. Using an in vivo myokine-labeling mouse model, we confirmed that the Serpina1 family of proteins are increased after 4 weeks of aerobic exercise. Systemic delivery of recombinant Serpina1e enhanced hippocampal memory formation, promoted hippocampal neurogenesis, and elevated BDNF levels. Moreover, plasma Serpina1e can cross the blood–cerebral spinal fluid (CSF) barrier and blood–brain barrier to reach the brain, thereby influencing hippocampal function. In vivo Serpina1e infusion also induced cognitive enhancement. Our findings suggest that Serpina1e is a myokine that migrates to the hippocampus and mediates exercise-induced memory enhancement by triggering neurotrophic growth signaling. This molecular mechanism underlying the beneficial effects of exercise on cognitive function may have implications for the development of therapeutic interventions for alleviating cognitive disorders. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_16:59:41.444.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sanghee Shin |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | biotinylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-05 18:23:57 | ID requested | |
| ⏵ 1 | 2026-06-14 16:59:42 | announced | |
Publication List
| 10.1038/s41467-026-71420-0; |
| Kim H, Shin S, Han J, Yun K, Kim JS, Park H, Serpina1e mediates the exercise-induced enhancement of hippocampal memory in male mice. Nat Commun, 17(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Exercise, hippocampus, cognitive enhancement, Serpina1e, skeletal muscle, memory, neurogenesis, BDNF, myokine |
Contact List
| Jong-Seo Kim |
|---|
| contact affiliation | School of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea Center for RNA Research, Institute of Basic Science, Seoul National University, Seoul, 08826, Republic of Korea |
| contact email | jongseokim@snu.ac.kr |
| lab head | |
| Sanghee Shin |
|---|
| contact affiliation | Dana-Farbar Cancer Institute
Harvard Medical School |
| contact email | sunnyshin54@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055604
- Label: PRIDE project
- Name: Serpina1e mediates the exercise-induced enhancement of hippocampal memory
