PXD055579

PXD055579 is an original dataset announced via ProteomeXchange.

Title	Proteomics of serotonergic autoregulation
Description	Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with depression to the most common antidepressive drugs inhibiting the serotonin transporter (SERT), a molecule responsible for the reuptake of serotonin and therefore for its quick removal from the synaptic cleft. However, the signaling pathways involved in autoregulation and the molecular alterations induced by serotonin on its autoreceptors are yet unclear. We aim at analysing changes in levels of proteins induced by longterm changes of serotonin levels in Raphe nuclei of mice with low and elevated serotonin release in the brain to reveal the signaling pathways involved in the autoregulation of serotonergic neurons.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_02:56:12.310.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oliver Popp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-05 03:49:32	ID requested
⏵ 1	2025-05-07 02:56:13	announced

Cao Y, Popp O, Milani N, Qadri F, K, ü, hn R, Mertins P, Bader M, Alenina N, Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice. Commun Biol, 7(1):1641(2024) [pubmed]

10.1038/s42003-024-07360-6;

submitter keyword: serotonin,Serotonin transporter, brain, tryptophan hydroxylase, autoregulation, mouse

Natalia Alenina
contact affiliation	Max-Delbrück Center for Molecular Medicine (MDC) Robert-Rössle-Str. 10, 13125 Berlin, Germany
contact email	alenina@mdc-berlin.de
lab head
Oliver Popp
contact affiliation	MDC Berlin
contact email	oliver.popp@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055579

PRIDE project URI

• PRIDE
  1. PXD055579
     1. Label: PRIDE project
     2. Name: Proteomics of serotonergic autoregulation