PXD055572
PXD055572 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Analysis of corona proteins adsorbing to Cas9 ribonucleoprotein-loaded lipid nanoparticles |
Description | Perotein corona is formed surrouding interface of nanopsrticles upon administered in biological fluids. The quality of protein corona is recognized as the crucial factor for in vivo fate of the administered nanoparticles. In this project, Cas9 ribnonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) capable of robust gene knockout of hepatic genes of interest after single intravenous injection were developed. Compared with short interfering RNA (siRNA)-loaded LNPs, RNP-loaded LNPs showed different morphology, biodistribution, and mechanism of hepatic acccumulation. Therefore, proteome analysis of the corona proteins on the RNP and siRNA-loaded LNPs were performed to elucidate the impact of payloads on nano-bio interactions. |
HostingRepository | jPOST |
AnnounceDate | 2024-09-05 |
AnnouncementXML | Submission_2024-09-04_22:59:28.208.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yusuke Sato |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Iodoacetanilide; unknown modification |
Instrument | instrument |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-09-04 22:59:24 | ID requested | |
⏵ 1 | 2024-09-04 22:59:28 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: corona protein, Cas9 ribonucleoprotein, lipid nanoparticles |
Contact List
Yusuke Sato | |
---|---|
lab head | |
Yusuke Sato | |
contact affiliation | Hokkaido University |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003357/ |