PXD055572

PXD055572 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Analysis of corona proteins adsorbing to Cas9 ribonucleoprotein-loaded lipid nanoparticles
Description	Perotein corona is formed surrouding interface of nanopsrticles upon administered in biological fluids. The quality of protein corona is recognized as the crucial factor for in vivo fate of the administered nanoparticles. In this project, Cas9 ribnonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) capable of robust gene knockout of hepatic genes of interest after single intravenous injection were developed. Compared with short interfering RNA (siRNA)-loaded LNPs, RNP-loaded LNPs showed different morphology, biodistribution, and mechanism of hepatic acccumulation. Therefore, proteome analysis of the corona proteins on the RNP and siRNA-loaded LNPs were performed to elucidate the impact of payloads on nano-bio interactions.
HostingRepository	jPOST
AnnounceDate	2024-09-05
AnnouncementXML	Submission_2024-09-04_22:59:28.208.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yusuke Sato
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Iodoacetanilide; unknown modification
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-04 22:59:24	ID requested
⏵ 1	2024-09-04 22:59:28	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: corona protein, Cas9 ribonucleoprotein, lipid nanoparticles

submitter keyword: corona protein, Cas9 ribonucleoprotein, lipid nanoparticles

Contact List

Yusuke Sato
lab head
Yusuke Sato
contact affiliation	Hokkaido University
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003357/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003357/