PXD055559

PXD055559 is an original dataset announced via ProteomeXchange.

Title	Fat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Description	Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We have previously used the laser microdissection and mass spectrometry (LMD/MS) to search for target antigens in PLA2R-negative MN. In this study, we used LMD/MS to search for the target antigen(s) in de novo MN. Our studies identified target antigen FAT1 in de novo MN when it is associated with concurrent antibody mediated rejection.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_07:51:50.487.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD055559
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benjamin Madden
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-04 11:10:32	ID requested
⏵ 1	2024-10-22 07:51:51	announced

10.6019/PXD055559;

10.1016/j.kint.2024.08.009;

Sethi S, Madden B, Casal Moura M, Nasr SH, Alexander MP, Debiec H, Torrel N, Gross L, Negron V, Specks U, Fervenza FC, Haas M, Ronco P, Batal I, FAT1 is a target antigen in a subset of de novo allograft membranous nephropathy associated with antibody mediated rejection. Kidney Int, 106(5):985-990(2024) [pubmed]

submitter keyword: kidney transplant.,FAT1, de novo membranous nephropathy

Sanjeev Sethi M.D. Ph.D.
contact affiliation	Consultant Pathology; Department of Laboratory Medicine
contact email	sethi.sanjeev@mayo.edu
lab head
Benjamin Madden
contact affiliation	Mayo Clinic
contact email	madden.benjamin@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD055559

PRIDE project URI

• PRIDE
  1. PXD055559
     1. Label: PRIDE project
     2. Name: Fat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.