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PXD055559

PXD055559 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
DescriptionMembranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We have previously used the laser microdissection and mass spectrometry (LMD/MS) to search for target antigens in PLA2R-negative MN. In this study, we used LMD/MS to search for the target antigen(s) in de novo MN. Our studies identified target antigen FAT1 in de novo MN when it is associated with concurrent antibody mediated rejection.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:51:50.487.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD055559
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterBenjamin Madden
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-04 11:10:32ID requested
12024-10-22 07:51:51announced
Publication List
10.6019/PXD055559;
10.1016/j.kint.2024.08.009;
Sethi S, Madden B, Casal Moura M, Nasr SH, Alexander MP, Debiec H, Torrel N, Gross L, Negron V, Specks U, Fervenza FC, Haas M, Ronco P, Batal I, FAT1 is a target antigen in a subset of de novo allograft membranous nephropathy associated with antibody mediated rejection. Kidney Int, 106(5):985-990(2024) [pubmed]
Keyword List
submitter keyword: kidney transplant.,FAT1, de novo membranous nephropathy
Contact List
Sanjeev Sethi M.D. Ph.D.
contact affiliationConsultant Pathology; Department of Laboratory Medicine
contact emailsethi.sanjeev@mayo.edu
lab head
Benjamin Madden
contact affiliationMayo Clinic
contact emailmadden.benjamin@mayo.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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